TABLE 2.
Antiproliferative effects on Leishmania amazonensis intracellular amastigotesa
| Compound | IC50 of intracellular amastigotes at 72 h (nM) | CC50 of peritoneal or RAW264.7 macrophages at 72 h (nM) | Selective index (CC50/IC50) |
|---|---|---|---|
| ITZ | 145.38 | 15,000 | 103.17 |
| Zn(ITZ)2Cl2 (1) | 0.118 | 600 | 5,084 |
| Zn(ITZ)2(OH)2 (2) | 33.07 | 800 | 24.19 |
| ZnCl2 | >10,000 | ||
| ZnAc2.2H2O | 10,000 |
a
Parasites were treated with different concentrations for 72 h to evaluate the growth inhibition. The inhibitors and zinc salts were added after 24 h of growth.