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Anti-Toxoplasma gondii activity and cytotoxicity against HFF cells of ITZ and Zn-ITZ complexesa
| Compound | IC50 (nM) by treatment time (h) |
Cytotoxicity values |
||
|---|---|---|---|---|
| 72 | 96 | CC50 (nM) | SI | |
| ITZ | 162.3 ± 43.6 | 196.1 ± 65.7 | >5,000 | >25.5 |
| Zn(ITZ)2Cl2 (1) | 37.2 ± 12.4* | 38.7 ± 9.1* | >5,000 | >129.2 |
| Zn(ITZ)2(OH)2 (2) | 60.0 ± 15.22* | 72.0 ± 33.8* | >5,000 | >69.4 |
Results are expressed as mean ± standard deviation of three different experiments. *, P value is <0.01 compared with ITZ IC50.
