TABLE 4.
Anti-Trypanosoma cruzi activity and cytotoxicity against LLC-MK2 cells of ITZ and Zn-ITZ complexesa
| Compound | IC50 (nM) of: |
Cytotoxicity values |
||
|---|---|---|---|---|
| Epimastigotesb | Intracellular amastigotesc | CC50 (nM) | SI | |
| ITZ | 87.0 ± 11.3 | 2.3 ± 0.87 | 152.5 | 66.3 |
| Zn(ITZ)2Cl2 (1) | 3.31 ± 2.57* | 1.14 ± 0.91* | 368.91 | 323.6 |
| Zn(ITZ)2(OH)2 (2) | 1.3 ± 1.8* | 0.91 ± 0.76* | 505.4 | 555.38 |
a
Results are expressed as mean ± standard deviation of three different experiments. *, P value is <0.01 compared with ITZ IC50.
b
Epimastigotes were treated with different concentrations for 48 h to evaluate the growth inhibition.
c
Amastigotes were treated for 72 h after 24 h of infection.