TABLE 5.
Anti-Sporothrix sp. effect and hemolytic activity of Zn-ITZ-complexes
| Compound | Antifungal activity (μM) of: |
Hemolytic activity (μM) |
|||||
|---|---|---|---|---|---|---|---|
|
Sporothrix brasiliensis |
Sporothrix schenckii |
||||||
| MIC | MFCa | MIC | MFC | HA50b | SIc for S. brasiliensis | SI for S. schenckii | |
| ITZ | 0.6 | >20 | 1.25 | >20 | 700 | 1,166.7 | 560 |
| Zn(ITZ)2Cl2 (1) | 0.08 | 20 | 0.08 | 2.5 | >1,000 | >12,500 | >12,500 |
| Zn(ITZ)2(OH)2 (2) | 0.3 | >20 | 0.16 | >20 | NDd | ND | ND |
| ZnCl2 | >20 | >20 | >20 | >20 | >1,000 | >50 | >50 |
| ZnAc2.2H2O | >20 | >20 | >20 | >20 | ND | ND | ND |
a
Minimum fungicidal concentration.
b
50% hemolytic concentration.
c
Selective index (SI) = HA50/MIC.
d
ND, not determined.