TABLE 1.

EC₅₀ values of different azoles, chlorhexidine, and PHMB against A. castellanii trophozoites

Compound	Strain	EC50 (μM)
		Mean	95% lower CLb	95% upper CLb
Azoles
Fluconazole	Ma	3% at 50 μMa
Itraconazole	Ma	54% at 50 μMa
Miconazole	Ma	6.9	5.8	8.3
Ketoconazole	Ma	1.8	1.4	2.0
Voriconazole	Ma	0.6	0.4	0.8
Clotrimazole	Ma	0.2	0.1	0.2
Posaconazole	Ma	0.045	0.039	0.051
	MEEI 0184	0.003	0.002	0.004
	CDC:V240	0.065	0.054	0.079
Isavuconazole	Ma	0.005	0.004	0.006
	MEEI 0184	0.026	0.023	0.028
	CDC:V240	<0.001	<0.001	0.001
Standards of care
Chlorhexidine	Ma	1.7	1.4	1.9
	MEEI 0184	1.0	0.9	1.1
	CDC:V240	1.1	1.0	1.2
PHMB	Ma	7.2	6.6	8.0
	MEEI 0184	4.6	3.0	7.1
	CDC:V240	11.8	10.5	13.4

^aFor two azoles, fluconazole and itraconazole, the value given is the percentage of growth inhibition at the highest tested concentration, as the mean EC₅₀ value was not identified.

^bCL, confidence limit.