TABLE 1.
Activity of plazomicin against 8,783 Enterobacterales from the United States, 2016–2017
| Organism | Isolates (n [cumulative %]) inhibited at MIC (mg/liter) of: |
MIC (mg/liter) |
Susceptible (FDA breakpointsa) (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | >128 | MIC50 | MIC90 | ||
| Enterobacteriaceae (n = 8,783) | 3,206 (67.2) | 2,029 (90.3) | 584 (97.0) | 227 (99.6) | 26 (99.9) | 3 (99.9) | 1 (99.9) | 1 (99.9) | 0 (99.9) | 6 (100.0) | 0.5 | 1 | 97.0 |
| CRE (n = 98) | 14 (76.5) | 16 (92.9) | 3 (95.9) | 2 (98.0) | 1 (99.0) | 0 (99.0) | 0 (99.0) | 0 (99.0) | 1 (100.0) | 0.25 | 1 | 95.9 | |
| Escherichia coli (n = 4,053) | 2,172 (58.0) | 1,491 (94.8) | 198 (99.7) | 12 (100.0) | 0.5 | 1 | 99.7 | ||||||
| Klebsiella pneumoniae (n = 1,771) | 192 (98.5) | 17 (99.4) | 2 (99.5) | 1 (99.6) | 0 (99.6) | 1 (99.7) | 0 (99.7) | 0 (99.7) | 0 (99.7) | 6 (100.0) | 0.25 | 0.5 | 99.5 |
| Klebsiella oxytoca (n = 361) | 172 (92.0) | 25 (98.9) | 3 (99.7) | 1 (100.0) | 0.5 | 0.5 | 99.7 | ||||||
| Klebsiella aerogenes (n = 270) | 104 (95.6) | 12 (100.0) | 0.25 | 0.5 | 100.0 | ||||||||
| Enterobacter cloacae species complex (n = 762) | 204 (95.9) | 24 (99.1) | 4 (99.6) | 2 (99.9) | 0 (99.9) | 1 (100.0) | 0.25 | 0.5 | 99.6 | ||||
| Serratia marcescens (n = 521) | 215 (44.1) | 271 (96.2) | 18 (99.6) | 1 (99.8) | 1 (100.0) | 1 | 1 | 99.6 | |||||
| Citrobacter freundii species complex (n = 159) | 85 (88.7) | 16 (98.7) | 1 (99.4) | 1 (100.0) | 0.5 | 1 | 99.4 | ||||||
| Citrobacter koseri (n = 85) | 27 (94.1) | 4 (98.8) | 1 (100.0) | 0.25 | 0.5 | 100.0 | |||||||
| Morganella morganii (n = 128) | 11 (8.6) | 53 (50.0) | 43 (83.6) | 18 (97.7) | 3 (100.0) | 1 | 4 | 83.6 | |||||
| Providencia spp. (n = 57) | 8 (14.0) | 15 (40.4) | 21 (77.2) | 5 (86.0) | 6 (96.5) | 0 (96.5) | 1 (98.2) | 1 (100.0) | 2 | 8 | 77.2 | ||
| Proteus mirabilis (n = 587) | 13 (2.7) | 85 (17.2) | 286 (65.9) | 184 (97.3) | 15 (99.8) | 1 (100.0) | 2 | 4 | 65.9 | ||||
| Proteus vulgaris group (n = 29) | 3 (10.3) | 16 (65.5) | 7 (89.7) | 2 (96.6) | 1 (100.0) | 1 | 4 | 89.7 | |||||
a
FDA breakpoints were accessed from reference 14.