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. 2020 Apr 15;11:466. doi: 10.3389/fphar.2020.00466

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Copyright © 2020 Lu, Huang, Zhang, Lan, Zhang, Tang, Xu, Zhao, Cong, Zhao, Sun, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism by which DDT inhibits oxidative stress and apoptosis in PC12 cells. AlCl₃-induced intracellular ROS accumulation, which causes intracellular oxidative stress and apoptosis. DDT up-regulates SIRT1-mediated PI3K/Akt signaling, which causes Nrf2 expression and nuclear translocation. Nrf2 activation enhances the downstream, HO-1 expression, which finally protects cells from oxidative stress and apoptosis.