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. 2020 Apr 9;8:180. doi: 10.3389/fcell.2020.00180

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Copyright © 2020 Yang, Tang, Lin, Wu, Zeng, Pan, Li, Xiang, Lin, Zhuang, Song, Jiang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of Exon4b-containing OPA1 isoforms in HCC. (A,B) mRNA levels of OPA1 isoforms with Exon4b (A) and OPA1 isoforms without Exon4b (B) in 22 paired HCC (T) and adjacent non-tumor (N) liver tissues (n = 22, paired-samples t-test **p < 0.01). (C,D) Relative TMRM fluorescence intensity (FI) (C, n = 3, biological replicates) and cellular ATP level (D, n = 3, biological replicates) in SK-Hep1 cells expressing ShExon4b compared to that in SK-Hep1 cells expressing ShLuc which is normalized to 1 (independent-samples t-test. *p < 0.05, **p < 0.01). (E) Model of the functions of OPA1 isoforms with or without Exon4b.