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. 2009 Jul 7;2(2):114–122. doi: 10.1159/000228159

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Copyright © 2010 by S. Karger AG, Basel

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Fig. 1 — Schematic representation of the alveolus and capillaries illustrating the potential roles of MBL in modulating respiratory tract infection. A As there is no local production of MBL, small amounts of the protein ‘leak’ into inflamed airways. B Lectin pathway-mediated killing may contribute to mucosal defences against pathogens such as Haemophilus influenzae. C MBL-facilitated phagocytosis of intracellular pathogens such as Mycobacterium tuberculosis may predispose to tuberculosis in MBL replete individuals. D MBL-facilitated opsonophagocytosis of Streptococcus pneumoniae may predispose to severe invasive disease in MBL deficient individuals.