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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Gastroenterology. 2019 Dec 17;158(4):1029–1043.e10. doi: 10.1053/j.gastro.2019.11.302

Figure 1. Oncogenic hotspot mutations observed in armadillo repeats 5 and 6 of β-catenin.

Figure 1.

Three amino acids are commonly mutated in cancers, i.e. K335, W383, and N387. Top panel shows overview of all reported amino acid substitutions along the β-catenin protein, while bottom panel shows mutations restricted to amino acids 310–440. Details such as involved cancer types can be explored interactively on the COSMIC website, but are also presented in Supplemental Table S1. The following alterations have been observed at least 4 times: Y333F 7x; E334K 8x; K335T 18x; K335I 46x; R376H 4x; W383C 12x; W383R 12x; W383G 7x; N387K 40x.