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. 2020 Apr 23;16(4):e1008653. doi: 10.1371/journal.pgen.1008653

Fig 2. Schematic representation showing various factors within Drosophila fat body, BBB glia, and NSCs that regulate Drosophila NSC quiescence entry and reactivation.

Fig 2

Factors promoting NSC reactivation are in green, while factors maintaining NSC quiescence or preventing reactivation are in red. Abd-A, Abdominal-A; ALH, after larval hatching; Ana, Anachronism; Antp, Antennapedia; BBB, blood–brain barrier; Cas, Caster; Cdc37, Cell division cycle 37; Chro, Chromator; Cka, Connector of kinase to AP-1; CRL4, Cullin-RING ligase 4; Dapp21, Dacapo (ortholog of p21CIP/p27KIP1/p57KIP2 family); dILPs, insulin/IGF-like peptides; D–V, dorsal to ventral; FDS, fat-body–derived signal; FMRP, Fragile X mental retardation protein; Grh, Grainy head; Hsp83, Heat shock protein 83; InR, Insulin receptor; Mob4, Monopolar spindle-one-binder family member 4; Msx/Msh, Muscle segment homeobox (ortholog of MSX1/2/3); Mts, Microtubule star; Nab, NGFI-A-binding protein; NKX/Vnd, Ventral nervous system defective (ortholog of NKX family); NSC, neural stem cell; Pdm, Pou-domain proteins Pdm1 and 2; PI3K, Phosphatidylinositol 3-kinase; Pros, Prospero; Slif, Slimfast; Sqz, Squeeze; TOR, Target-of-Rapamycin; Trol, Terribly reduced optic lobes.