Table 3. Univariate Cox regression analysis for MAGS-assigned clinical cohorts (GSE6891 cohort: N = 520; TCGA-cohort: N = 171) and the corresponding AML meta-cohort (N = 691) that included both clinical cohorts.
Analyses were performed for overall survival. Samples with missing survival information (TCGA cohort: N = 11) were excluded. Table columns indicate the total sample size (N), the number of patients that died (Events) per MAGS subtype, the associated hazards ration (HR), the 95% lower and upper confidence intervals (CI), and the estimated p-value (P).
| N | Events | HR | 95% CI | P | |
|---|---|---|---|---|---|
| TCGA cohort | |||||
| HSC | 48 | 40 | 1 | ||
| MEP | 44 | 22 | 0.44 | 0.26–0.74 | 1.90e-03** |
| GMP | 52 | 34 | 0.68 | 0.43–1.08 | 0.1 |
| UC | 27 | 14 | 0.37 | 0.20–0.69 | 1.63e-03** |
| GSE6891 cohort | |||||
| HSC | 146 | 115 | 1 | ||
| MEP | 134 | 77 | 0.53 | 0.40–0.71 | 2.13e-05*** |
| GMP | 162 | 101 | 0.63 | 0.48–0.83 | 7.86e-04*** |
| UC | 78 | 52 | 0.70 | 0.51–0.98 | 0.03 |
| Meta-cohorta | |||||
| HSC | 194 | 155 | 1 | ||
| MEP | 178 | 99 | 0.51 | 0.40–0.65 | 1.46e-07*** |
| GMP | 214 | 135 | 0.64 | 0.51–0.81 | 1.64e-04*** |
| UC | 105 | 66 | 0.60 | 0.45–0.80 | 5.32e-04*** |
a Analysis of the meta-cohort was corrected for potential batch effects by including the cohort (TCGA, GSE6891) as an independent explanatory variable.
Significance levels:
* ≤ 0.05;
** ≤0.01;
*** ≤ 0.001;
Abbreviations: HSC, hematopoietic stem cells; GMP, granulocytic-monocytic progenitors; MEP, megakaryocyte-erythroid progenitors; UC, unclassified samples (assignment frequency of UC = 15%);