Table 2. Summary of histopathological findings in Gd-treated and control mice (N = 9 and 8, respectively).
| ID | age [w] | Brain | heart | lung | liver | spleen | kidney | GIT | |
|---|---|---|---|---|---|---|---|---|---|
| control | 360 | 94,3 | - | - | - | vvv | - | - | - |
| 361 | 94,3 | - | - | - | Vvv | - | ii | - | |
| 362 | 94,3 | - | - | - | Vv | c | i | - | |
| 363 | 94,3 | - | - | - | Vv | c vascular pathology | ii | - | |
| 364 | 94,3 | - hemorrhage in 4th ventricle | - | i | Vvv | c | ii | - | |
| 366 | 94,3 | - | - | - | Vvv | - | ii | - | |
| 367 | 94,3 | - | - | - | Vvv | - | - | - | |
| 368 | 94,3 | - | - | - | Vvv | - | - | - | |
| 476 | 94,9 | - mild gliosis (GFAP) | - | ii | Vv | cc | iii | - | |
| Gd-exposure | 389 | 93,7 | autolytic | ||||||
| 393 | 94,3 | - | - | - hemorrhage | Vvv | c | i | - | |
| 394 | 90,0 | autolytic | |||||||
| 395 | 94,3 | - | - | - | Vv | c | i | - | |
| 396 | 94,3 | - | - | - | Vvv | c | - | - | |
| 490 | 94,9 | - | - | ii | Vv | ccc | i | - | |
| 491 | 94,9 | - | - | ii tumor | vv cellular inflitrates | cc | i | - | |
| 493 | 94,9 | - mild gliosis (GFAP) | - | ii | Vv | - | - | - | |
In general, mice did not show pathological alterations in heart or gastrointestinal tract (GIT). No gross cellular alterations could be found in the CNS, despite two mice (N = 1 within each group) showing mild gliosis in the hippocampus (g). Cellular infiltrates could be found in the lung and kidneys (i). The liver showed hepatocellular vacuolization due to fatty change (v). A loss of nucleated cells could be found in the red pulp of the spleen (c). All pathological alterations could be found to a mild, moderate, or severe extent, respectively (x, xx, xxx). Two mice died before the planned end point and could not be examined because of necrotic changes in nearly all organs due to autolysis.