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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Bioorg Med Chem. 2020 Jan 31;28(6):115349. doi: 10.1016/j.bmc.2020.115349

Figure 1.

Figure 1.

Chemical structures of ritonavir and the most potent/high affinity CYP3A4 inhibitors, 8f and 4e-h, from the previously designed series II and III, respectively.15–16 The R1 and R2 side-groups are indicated. In ritonavir, the phenyl side-groups would be in R,R configuration if the hydroxyl group is removed.