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A and B, The binding mode of 7a and 7b. The adjacent I-helix and F304 in the inhibitory complexes and water-bound CYP3A4 (4I3Q structure) are shown in black and gray, respectively. Polder omit maps contoured at 3σ level are shown as green mesh.
C, Superposition of the 7a/b-bound CYP3A4 (6UNH and 6UNI structures, respectively.
