Fig 2. Combination index plots for the anti-P. falciparum activity of ivermectin (Ivm), verapamil (Vpl) or elacridar (Elc) in combination with doxycycline (Dox) against P. falciparum.

The data are representative of three independent experiments in duplicate for each combination. The 72h assays were performed on asynchronous cultures of P. falciparum, while the 96h assays were performed on synchronous cultures of the parasites with a medium change after 24h (see M&M for details). Combination of Ivm-Dox (from A to D); combination of Vpl-Dox (from E to H); combination of Elc-Dox (From I to L).