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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Trends Biochem Sci. 2020 Mar 5;45(5):440–453. doi: 10.1016/j.tibs.2020.02.002

Figure 3. Lis1 promotes the assembly of two dynein dimers onto dynactin.

Figure 3.

(1) Lis1 preferentially binds to and stabilizes dynein when it is in the ‘open’ conformation. (2) Dynein has a higher affinity for dynactin in the open conformation. (3) Lis1 recruits a second open dynein to dynactin. (4) Lis1 dissociates from most of the activated two dynein complexes after the assembly.