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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Trends Biochem Sci. 2020 Mar 5;45(5):440–453. doi: 10.1016/j.tibs.2020.02.002

Figure 4. Cargo adaptors link dynein to intracellular cargos.

Figure 4.

Schematic representation of the intracellular cargoes that dynein transports within the cell. Cargo adaptors that are confirmed through in vitro reconstitution to activate dynein are shown in regular font, while hypothesized adaptors are italicized. Question marks indicate cargos where the identity of the adaptor remains unknown. Arrows indicate direction of intracellular cargo transport. Abbreviations: MP, misfolded proteins; RE, recycling endosome; LE, late endosome; EE, early endosome; GA, Golgi apparatus; ER, endoplasmic reticulum; RNP, ribonucleic particle; TRAK1, trafficking kinesin-binding protein 1 (also known as OIP-106); TRAK2, trafficking kinesin-binding protein 2 (also known as GRIF-1); HAP1, huntingtin-associated protein 1; JIP3, JNK-interacting protein 1; RAB11FIP3, Rab11 family-interacting protein 3; BICD, Bicaudal D; BICDl/2, Bicaudal D homologue 1/2; BICDLl/2, BICD family-like protein 1/2; NINL, Ninein-like protein.