Table 1.

The list of cargo adaptors that recruit dynein to intracellular cargos.

Adaptor	Intracellular Cargo	Known binding partners (not including dynein and dynactin)	Evidence of dynein interaction	Demonstration of dynein activation	Refs
BicD1	Golgi-derived vesicles, cytoplasmic vesicles	Rab6a, Rab6b	Proteomics	N/A	[17]
BicD2	Golgi-derived vesicles, cytoplasmic vesicles	Rab6a, KIF5B	Co-IP, In vitro reconstitution	In vitro reconstitution	[60,61]
BicDL-1	Secretory vesicles	KIF1C, Rab6a, Rab6b	Co-IP, In vitro reconstitution	In vitro reconstitution	[64]
HOOK1	Late endosomes	FTS, AKTIP	Co-IP	Cell lysate isolation	[65,154]
HOOK2	Golgi-derived vesicles	FTS, AKTIP	Co-IP	N/A	[155]
HOOK3	Secretory vesicles	KIF1C	Co-IP, In-vitro reconstitution	In vitro reconstitution	[61,62]
SPDL1	Kinetochore	KNTC1, ZW10	Co-IP	Cell lysate isolation	[61,82]
Rab11FIP3	Recycling endosomes	Rab11a	Co-IP	Cell lysate isolation	[61]
NINL	Centrosome	APC	Co-IP, In-vitro reconstitution	In vitro reconstitution	[17]
NIN	Centrosome	GSK3β	Co-IP, In-vitro reconstitution	In vitro reconstitution	[17]
CRACR2a	Endosomes	ORAI1, STIM1	Co-IP, In-vitro reconstitution	In vitro reconstitution	[63]
Rab45	Endosomes	N/A	Co-IP, In-vitro reconstitution	In vitro reconstitution	[63]
CCDC88A	Endosomes	DISC1, AKT1	Co-IP	N/A	[17]
CCDC88B	Lytic granules	DOCK8, HSPA5	N/A	N/A	[17]
CCDC88C	N/A	DVL1	Co-IP	N/A	[17]
NUMA1	Microtubules	LGN, RAE1, SPAG5	IP	N/A	[80]
TRAK1	Mitochondria	KIF5B, Miro	Co-IP	N/A	[66]
TRAK2	Mitochondria, Peroxisomes	KIF5A, KIF5C	Co-IP	N/A	[66]
HAP1	Autophagosomes, BDNF-containing vesicles,	HTT, KIF5B	Indirect IP (interaction with dynactin)	N/A	[75]
RILP	Late endosomes, lysosomes	Rab7, Rab36	Co-IP	N/A	[156]
JIP3	APP vesicles, lysosomes, JNK	APP	Indirect IP	N/A	[157]