Table 2. Prevalence of iron deficiency in women by HFE p.C282Y and p.H63D allelesa.
| Race | Age, y | HFE allele | 0 alleles, % (n subjects) | Any allele, % (n subjects) | Value of p (0 vs. any alleles) |
|---|---|---|---|---|---|
| Hispanic | 25–54 | p.C282Y | 6.19 (6,528) | 8.47 (177) | 0.2076 |
| Hispanic | 25–54 | p.H63D | 6.19 (5,473) | 6.49 (1,232) | 0.6960 |
| Hispanic | ≥55 | p.C282Y | 1.13 (1,771) | 0.00 (61) | 1.0000 |
| Hispanic | ≥55 | p.H63D | 1.22 (1,475) | 0.56 (357) | 0.3990 |
| Black | 25–54 | p.C282Y | 6.00 (11,486) | 7.51 (253) | 0.2874 |
| Black | 25–54 | p.H63D | 6.01 (11,091) | 6.33 (648) | 0.7340 |
| Black | ≥55 | p.C282Y | 0.65 (5,370) | 0.70 (142) | 0.6104 |
| Black | ≥55 | p.H63D | 0.68 (5,176) | 0.30 (336) | 0.7233 |
| White | 25–54 | p.C282Y | 2.95 (13,666) | 2.69 (1,747) | 0.5975 |
| White | 25–54 | p.H63D | 2.95 (11,214) | 2.83 (4,199) | 0.7472 |
| White | ≥55 | p.C282Y | 0.76 (9,911) | 0.76 (1,192) | 1.0000 |
| White | ≥55 | p.H63D | 0.83 (8,173) | 0.55 (2,930) | 0.1368 |
| Asian | 25–54 | p.C282Y | 3.12 (4,741) | 12.50 (8) | 0.2252 |
| Asian | 25–54 | p.H63D | 3.08 (4,345) | 3.71 (404) | 0.4562 |
| Asian | ≥55 | p.C282Y | 0.38 (2,864) | 0.00 (2) | 1.0000 |
| Asian | ≥55 | p.H63D | 0.38 (2,615) | 0.40 (251) | 1.0000 |
| Pacific Islander | 25–54 | p.C282Y | 4.49 (245) | 11.11 (9) | 0.3577 |
| Pacific Islander | 25–54 | p.H63D | 5.33 (225) | 0.00 (29) | 0.3706 |
| Pacific Islander | ≥55 | p.C282Y | 1.05 (190) | 0.00 (5) | 1.0000 |
| Pacific Islander | ≥55 | p.H63D | 1.09 (183) | 0.00 (12) | 1.0000 |
| Native American | 25–54 | p.C282Y | 7.36 (299) | 0.00 (9) | 1.0000 |
| Native American | 25–54 | p.H63D | 7.88 (241) | 4.48 (67) | 0.4303 |
| Native American | ≥55 | p.C282Y | 0.86 (116) | 0.00 (11) | 1.0000 |
| Native American | ≥55 | p.H63D | 0.97 (103) | 0.00 (24) | 1.0000 |
| Otherb | 25–54 | p.C282Y | 4.39 (775) | 2.00 (50) | 0.7167 |
| Otherb | 25–54 | p.H63D | 4.46 (672) | 3.27 (153) | 0.6582 |
| Otherb | ≥55 | p.C282Y | 0.25 (399) | 0.00 (25) | 1.0000 |
| Otherb | ≥55 | p.H63D | 0.28 (362) | 0.00 (62) | 1.0000 |
aIron deficiency was defined as the combination of initial screening transferrin saturation <10% and initial screening serum ferritin <33.7 pmol/L (<15 μg/L). Values of p were obtained using Fisher’s exact test (two-tailed). NA = not available. HFE p.C282Y/p.H63D compound heterozygotes were counted once for each allele. Similar analyses that excluded p.C282Y/p.H63D compound heterozygotes revealed results consistent with those above (data not shown).
bParticipants who reported two or more race/ethnicity groups or unknown race/ethnicity were classified as Other.