Table 4. HFE p.C282Y and p.H63D alleles in iron-deficient women by pregnancya.
| Race | Pregnancy | HFE allele | 0 alleles, % (n subjects) | Any allele, % (n subjects) | Value of p |
|---|---|---|---|---|---|
| Hispanic | Yes | p.C282Y | 7.79 (552) | 9.09 (11) | 0.5949 |
| Hispanic | Yes | p.H63D | 8.37 (466) | 5.15 (97) | 0.4045 |
| Hispanic | No | p.C282Y | 6.13 (5,257) | 7.51 (173) | 0.4220 |
| Hispanic | No | p.H63D | 6.00 (4,397) | 6.87 (1,033) | 0.3142 |
| Black | Yes | p.C282Y | 3.31 (362) | 14.29 (7) | 0.2237 |
| Black | Yes | p.H63D | 3.70 (351) | 0.00 (18) | 1.0000 |
| Black | No | p.C282Y | 6.08 (9,887) | 7.66 (222) | 0.3204 |
| Black | No | p.H63D | 6.10 (9,561) | 6.39 (548) | 0.7830 |
| White | Yes | p.C282Y | 4.90 (735) | 1.57 (127) | 0.1035 |
| White | Yes | p.H63D | 4.62 (628) | 3.85 (234) | 0.7119 |
| White | No | p.C282Y | 2.87 (12,456) | 2.53 (1,895) | 0.4567 |
| White | No | p.H63D | 2.88 (10,205) | 2.68 (4,146) | 0.5408 |
| Asian | Yes | p.C282Y | 4.97 (181) | NA | - |
| Asian | Yes | p.H63D | 5.17 (174) | 0.00 (7) | 1.0000 |
| Asian | No | p.C282Y | 3.13 (4,254) | 12.50 (8) | 0.2257 |
| Asian | No | p.H63D | 3.11 (3,889) | 3.49 (373) | 0.6420 |
| Pacific Islander | Yes | p.C282Y | 6.25 (16) | NA | - |
| Pacific Islander | Yes | p.H63D | 7.14 (14) | 0.00 (2) | 1.0000 |
| Pacific Islander | No | p.C282Y | 4.17 (216) | 11.11 (9) | 0.3408 |
| Pacific Islander | No | p.H63D | 5.00 (200) | 0.00 (25) | 0.6072 |
| Native American | Yes | p.C282Y | 26.32 (19) | 0.00 (1) | 1.0000 |
| Native American | Yes | p.H63D | 27.78 (18) | 0.00 (2) | 1.0000 |
| Native American | No | p.C282Y | 6.61 (257) | 0.00 (11) | 1.0000 |
| Native American | No | p.H63D | 6.93 (202) | 4.55 (66) | 0.7711 |
| Otherb | Yes | p.C282Y | 3.70 (27) | 0.00 (1) | 1.0000 |
| Otherb | Yes | p.H63D | 3.70 (27) | 0.00 (1) | 1.0000 |
| Otherb | No | p.C282Y | 4.20 (690) | 3.70 (54) | 1.0000 |
| Otherb | No | p.H63D | 4.36 (597) | 3.40 (147) | 0.8178 |
aIron deficiency was defined as the combination of initial screening transferrin saturation <10% and initial screening serum ferritin <33.7 pmol/L (<15 μg/L). Values of p were obtained using Fisher’s exact test (two-tailed). NA = not available. HFE p.C282Y/p.H63D compound heterozygotes were counted once for each allele. Similar analyses that excluded p.C282Y/p.H63D compound heterozygotes revealed results consistent with those above (data not shown).
bParticipants who reported two or more race/ethnicity groups or unknown race/ethnicity were classified as Other.