Table 2. Comparison of histologic findings between patients with HSPN and IgAN.

	HSPN	IgAN	P value
Characteristics	(n = 24)	(n = 56)
ISKDC classificationa, No (%)
I	0 (0%)
II	4 (16.7%)
IIIa	20 (83.3%)
IIIb	0 (0%)
IV	0 (0%)
Histological grade according to JSNb, No (%)
I		18 (32.1%)
II		19 (33.9%)
III		19 (33.9%)
IV		0 (0%)
Global sclerosis ratec (%)	7.3 ± 10.3	19.4 ± 17.2	0.002
Crescent ratec (%)	5.4 ± 8.0	16.2 ± 18.2	0.006
Global sclerosis + crescent ratec (%)	14.4 ± 21.5	35.8 ± 20.9	<0.001
Oxford classificationd, No (%)
M1	12 (50.0%)	45 (80.3%)	0.006
E1	18 (75.0%)	13 (23.2%)	<0.001
S1	10 (41.6%)	16 (28.6%)	0.195
T1-2	0 (0%)	15 (26.8%)	0.003
C1-2	12 (50%)	41 (73.2%)	0.044
Glomerular deposition on IF staining
IgA: weake	2 (8.3%)	10 (17.8%)	0.331
IgA: moderatee	10 (41.7%)	29 (51.8%)	0.407
IgA: stronge	12 (50.0%)	17 (30.4%)	0.094
IgG deposition	9 (37.5%)	15 (26.8%)	0.489
Fibrin deposition,	21 (87.5%)	6 (10.7%)	<0.001
Electron dense deposit, No (%)
Mesangial area	23 (95.8%)	55 (98.2%)	0.087
Subendothelial area	11 (45.8%)	3 (5.4%)	<0.001

Value are means ± SD or (percent). Mann-Whitney U test or Fisher’s test are used for statistical analysis.

Abbreviations: HSPN; Henoch-Schönlein purpura nephritis, IgAN; Immunoglobulin A nephropathy; ISKDC, International Study of Kidney Disease in Children; JSN, Japanese Society of Nephrology, IF; immunofluorescence.

^aHistologic classification in HSPN was graded based on the ISKDC classification [35].

^bHistological grade in IgAN was classified according to the criteria of the JSN [36].

^cRates of global sclerosis, crescents, and both types of glomerular lesions (%) were calculated by dividing total number of each type of lesion by total number of glomeruli. Crescents comprise cellular, fibrocellular, and fibrous types.

^dHistological severity was graded according to Oxford classification [37].

^eIntensity of IgA deposition was described earlier [31].