Table 5.
Major oncogenic substrate recognition proteins
| Substrate recognition protein | Physiological evidence (knockout or transgenic mouse models) | Pathological evidence (cancer relevant human specimens) | Biochemical evidence (cancer relevant substrates) |
|---|---|---|---|
| DCAF1 | NA | Overexpressed in ovarian cancer136, colon cancer109 | LATS1/2139,140, Dicer1109, NF2141 |
| DCAF2 | NA | Overexpressed in head and neck squamous cell carcinoma149, melanoma150, ovarian cancer123, Ewing sarcoma151 | CDT1150,152, p21150, SET8150 |
| DCAF4L2 | NA | Overexpressed in colorectal cancer276 | PPM1B276 |
| DCAF6 | NA | Overexpressed in prostate cancer154 | NA |
| DCAF13 | NA | Overexpressed in hepatocellular carcinoma155 | NA |
| AhR | NA | Overexpressed in liver cancer321, thyroid cancer322 | NA |
| COPS8 | NA | NA | CENP-A323 |
| FBXO44 | NA | Overexpressed in breast cancer324 | NA |
| FBXW5 | NA | NA | DLC1289, TSC2290,325 |
| HBx | Hepatocarcinogenesis in transgenic Hbx mice129,130 | Overexpressed in liver cancer131, intrahepatic cholangiocarcinoma132, adenoid cystic carcinoma133 | NA |
| RBBP7 | NA | NA | CENP-A292,323 |
| STRAP | NA | Overexpressed in colon cancer326, lung cancer326 | NA |
| HOXB4 | NA | Overexpressed in acute myeloid leukemia327, nephroblastoma328 | Geminin329 |