. Author manuscript; available in PMC: 2020 Apr 23.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2019 Mar 25;46(2):155–163. doi: 10.1007/s10928-019-09626-7

Table 2.

Ratios of Poor Metabolizers to Extensive Metabolizers and Ultra-Rapid Metabolizers to Extensive Metabolizers following Oral Dosing of Metoprolol, a High ER_H CYP2D6 Substrate [8]

	AUC Ratio	t_{½,term,1st dose} Ratio	C_{max,1st dose} Ratio
Poor	4.86	2.32	2.28
Extensive

Ultra-Rapid	0.37	0.90	0.43
Extensive