Table 2.
Daily Doses of Oral Phosphate and Active Vitamin D in the Conventional Therapy Group
| Visit | Oral phosphate, mg/kg (N=32) | Oral calcitriol, ng/kg (N=22) | Oral alfacalcidol, ng/kg (N=9)a | |||
|---|---|---|---|---|---|---|
| Statistic | Median (Q1, Q3) | Mean (SD) (min, max) | Median (Q1, Q3) | Mean (SD) (min, max) | Median (Q1, Q3) | Mean (SD) (min, max) |
| Baseline | 32·0 (25·6, 52·9) | 36·2 (16·0) (10·4, 73·6) | 21·2 (15·9, 26·7) | 21·6 (7·4) (6·8, 34·6) | 62·3 (34·5, 104·7) | 78·1 (66·4) (17·0, 224·1) |
| Week 40 | 35·3 (28·4, 50·5) | 41·0 (20·7) (18·1, 109·5) | 22·3 (17·5, 32·7) | 26·4 (13·3) (6·8, 63·5) | 79·7 (40·2, 104·7) | 87·1 (61·4) (27·6, 224·1) |
| Week 64 | 39·3 (28·7, 52·9) | 45·8 (27·7) (18·1, 166·2) | 26·4 (17·3, 34·2) | 27·2 (13·4) (6·8, 63·5) | 79·8 (40·2, 104·7) | 86·5 (59·6) (27·6, 217·4) |
Previously published recommended dosing ranges: Oral phosphate 20–60 mg/kg/day divided into three to five doses per day, alfacalcidol 40–60 ng/kg/day or calcitriol 20 to 30 ng/kg/day taken once or divided into two or three doses per day.1,5
a
One patient was not included in the oral alfacalcidol results because this patient received eldecalcitol (19.5 ng/kg/day) at baseline and switched to alfacalcidol at Week 32 (11.2 ng/kg/day, with no dose adjustments thereafter).