Table 3.
Univariate association of baseline factors with disability at 18 months
| Measure (scale range*) | Flowers | HAP/KPS | ||||
|---|---|---|---|---|---|---|
| Number Evaluated | OR (95% CI) | P | Number Evaluated | OR (95% CI) | P | |
| Alkaline phosphatase, U/dL | 356 | 1.00 (0.99–1.02) | 0.55 | 251 | 0.99 (0.97–1.01) | 0.38 |
| Alkaline phosphatase/upper limit of normal ratio | 356 | 0.98 (0.89–1.07) | 0.61 | 251 | 0.83 (0.65–1.06) | 0.05 |
| Alanine aminotransferase, U/dL | 359 | 0.99 (0.98–1.01) | 0.36 | 254 | 0.98 (0.95–1.01) | 0.07 |
| Alanine aminotransferase/ULN ratio | 359 | 0.97 (0.91–1.04) | 0.41 | 254 | 0.89 (0.77–1.03) | 0.06 |
| Total serum bilirubin, mg/dL | 360 | 0.75 (0.56–1.00) | 0.009 | 255 | 0.41 (0.16–1.07) | 0.007 |
| Total serum bilirubin/ULN ratio | 360 | 0.67 (0.46–0.98) | 0.007 | 255 | 0.35 (0.11–1.14) | 0.01 |
| Esophagus score (0–3) | 371 | 1.66 (1.15–1.91) | 0.004 | 261 | 1.19 (0.78–1.80) | 0.43 |
| Upper gastrointestinal score (0–3) | 371 | 1.23 (0.90–1.67) | 0.18 | 261 | 0.76 (0.45–1.28) | 0.28 |
| Lower gastrointestinal score (0–3) | 369 | 0.89 (0.61–1.30) | 0.55 | 259 | 0.79 (0.45–1.38) | 0.38 |
| Oral erythema score (0–3) | 370 | 1.48 (1.15–1.91) | 0.002 | 260 | 0.86 (0.60–1.23) | 0.41 |
| Oral lichenoid score (0–3) | 370 | 1.28 (1.04–1.56) | 0.02 | 260 | 0.86 (0.66–1.14) | 0.29 |
| Oral ulcer score (0–6) | 369 | 1.02 (0.87–1.19) | 0.79 | 259 | 1.00 (0.80–1.25) | 0.97 |
| Oral sum score (0–12) | 371 | 1.08 (1.00–1.17) | 0.04 | 261 | 0.95 (0.85–1.07) | 0.42 |
| Ankle range of motion score (1–4) | 330 | 0.96 (0.65–1.42) | 0.83 | 229 | 0.95 (0.54–1.64) | 0.84 |
| Elbow range of motion score (1–7) | 331 | 0.80 (0.58–1.11) | 0.17 | 228 | 0.71 (0.48–1.04) | 0.08 |
| Shoulder range of motion score (1–7) | 333 | 0.76 (0.56–1.03) | 0.07 | 230 | 0.68 (0.47–0.98) | 0.04 |
| Wrist and finger range of motion score (1–7) | 332 | 0.85 (0.69–1.04) | 0.10 | 230 | 0.97 (0.74–1.29) | 0.85 |
| Joint range of motion sum score (4–25) | 328 | 0.92 (0.83–1.01) | 0.06 | 228 | 0.93 (0.83–1.05) | 0.27 |
| Eye score (0–3) | 370 | 2.87 (1.87–4.38) | <.0001 | 260 | 1.83 (1.02–3.30) | 0.04 |
| Genital score (0–3) | 253 | 3.03 (1.42–6.47) | 0.003 | 178 | 2.29 (0.92–5.70) | 0.08 |
| Gastrointestinal tract score (0–3) | 371 | 1.13 (0.74–1.73) | 0.56 | 261 | 1.04 (0.58–1.88) | 0.89 |
| Joints/fascia score (0–3) | 371 | 1.64 (1.08–2.48) | 0.02 | 261 | 1.24 (0.70–2.19) | 0.46 |
| Lung score (0–3) | 371 | 1.39 (0.86–2.24) | 0.17 | 261 | 1.19 (0.62–2.26) | 0.60 |
| Mouth score (0–3) | 371 | 1.88 (1.23–2.88) | 0.003 | 261 | 1.25 (0.69–2.23) | 0.46 |
| Skin score (0–3) | 371 | 1.90 (1.20–3.02) | 0.006 | 261 | 1.19 (0.63–2.27) | 0.59 |
| Forced expiratory volume in first second, percent of predicted | 187 | 0.80 (0.67–0.95) | 0.01 | 125 | 0.89 (0.70–1.14) | 0.36 |
| LSS Summary symptom score (0–100) | 322 | 1.68 (1.38–2.03) | <.0001 | 261 | 1.33 (1.08–1.63) | 0.007 |
| LSS Energy subscale (0–100) | 322 | 1.18 (1.06–1.31) | 0.002 | 261 | 1.13 (0.99–1.29) | 0.07 |
| LSS Eye subscale (0–100) | 321 | 1.20 (1.11–1.29) | <0.0001 | 260 | 1.10 (1.01–1.20) | 0.04 |
| LSS Lung subscale (0–100) | 322 | 1.24 (0.98–1.56) | 0.07 | 261 | 1.10 (0.84–1.44) | 0.50 |
| LSS Mouth subscale (0–100) | 322 | 1.16 (1.07–1.25) | <0.0001 | 261 | 1.10 (1.01–1.20) | 0.03 |
| LSS Nutrition subscale (0–100) | 322 | 1.18 (0.99–1.39) | 0.05 | 261 | 1.10 (0.89–1.34) | 0.39 |
| LSS Psych subscale (0–100) | 321 | 1.14 (1.02–1.26) | 0.02 | 261 | 1.11 (0.98–1.27) | 0.11 |
| LSS Skin subscale (0–100) | 322 | 1.22 (1.10–1.36) | 0.0001 | 261 | 1.11 (0.98–1.27) | 0.11 |
| Number of Flowers features (0–2) | 371 | 0.97 (0.67–1.41) | 0.89 | 261 | 1.26 (0.76–2.09) | 0.38 |
| HAP score (25–94) | 320 | 0.88 (0.75–1.03) | 0.12 | 261 | 1.49 (1.18–1.88) | 0.0005 |
| Karnofsky performance status (0–100) | 317 | 0.90 (0.76–1.07) | 0.23 | 259 | 1.43 (1.13–1.80) | 0.002 |
ULN = upper limit of normal
LSS – Lee Symptom Scale
Variables with p<0.05 are indicated in bold