Table 2.
Comparison of Metabolite Levels in Different Matrices as a Function of Age
| Specimen | Total GABA | GHB | Metabolite |
||
|---|---|---|---|---|---|
| Acylcarnitines | Amino Acid | Guanidino- Species | |||
| DBS (newborn)1,2 | – | ↑ | ↓C2, C3, C4, C4OH | ↓Ornithine | ↓Creatine |
| DBS1,2 (post-newborn) | – | ↑(nl ~10 yrs) | ↓C2, C4OH | ↓Ornithine, Histidine | ↓Creatine |
| Plasma3 | ↑(nl ~30–40 yrs) | ↑(nl ~10 yrs) | – | – | – |
| PM Tissue4 | ↑(age 37 yrs) | ↑(age 37 yrs) | ↓C4OH, C5, C5:1 | ↓Serine, Glutamine | ↓Creatine |
| ↑C5DC, C12OH | ↑Aspartic acid | ↑Guac | |||
Abbreviations: GABA, γ-aminobutyric acid; GHB, γ-hydroxybutyric acid; nl, normalized (within range of controls); Guac, guanidinoacetic acid; DBS, dried bloodspots; PM, post-mortem. For description of acylcarnitine species, see text. Upward pointing arrows indicate elevations, while downward pointing arrows indicate decreased levels
References-
4
Current report