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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Mar 19;40(5):1207–1219. doi: 10.1161/ATVBAHA.120.313997

Figure 5: NAPQI relaxes preconstricted mesenteric arteries by stimulating CGRP release.

Figure 5:

Representative isometric tension recordings showing the effect of increasing concentrations of NAPQI in preconstricted (•) rat mesenteric arteries (A) pre-treated with, and in the presence of capsaicin, and (B) in the presence of AMG9810.

(C) (i) Mean data showing the effect of NAPQI on changes in tension of preconstricted rat mesenteric arteries in control arteries (n=14), in the presence of BIBN 4096 (n=7), capsaicin (n=7) and BIBN 4096 with capsaicin (n=7). (ii) Mean data showing the effect of NAPQI on changes in tension of preconstricted rat mesenteric arteries in control arteries (n=14), in the presence of BIBN 4096 (n=7), AMG9810 (n=7) and BIBN 4096 with AMG9810 (n=7). (D) BIBN 4096, capsaicin and AMG9810 all attenuated the LogEC50 for NAPQI significantly (according to a one-way ANOVA followed by a Tukey multiple comparisons test, ** and *** denote P<0.01 and P<0.001, respectively).