FIGURE 1.

Chronic social defeat stress (CSDS) increases anxiety-like behavior in mice. (A) Schematic showing procedures for unstressed control mice and CSDS mice. Anxiety-like behavior was measured by open field test (OFT) and elevated plus maze (EPM). (B) Representative activity tracking in the OFT in control and CSDS mice. (C) Time in center area. (D) Center area entries. (E) Representative activity tracking in the EPM in control and CSDS mice. (F) Elevated plus maze test open arm time. (G) Elevated plus maze test open arm entries. ***p < 0.001. Pooled data are presented as mean ± SEM.