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. 2020 Apr 17;14:299. doi: 10.3389/fnins.2020.00299

FIGURE 2.

FIGURE 2

Chronic social defeat stress increases tonic GABAAR currents in Thy1+ neurons, but reduces those in Thy1- neurons, in BLA. (A) Representative image showing the expression of Thy1–YFP in amygdala. CaMKIIα was used as a marker for projection neurons (PNs). The scale bar represents 100 μm. (B) Schematic showing whole-cell patch clamp recording of PNs in amygdala. (C) Infrared DIC (left) or fluorescent (right) images of Thy1+ neurons (green arrow heads) and Thy1- neurons (yellow arrowheads). The scale bar represents 15 μm. (D) Representative traces of THIP-induced tonic GABAAR currents recorded in Thy1+ and Thy1- neurons from control and CSDS mice. (E) Average of THIP-induced tonic GABAAR currents between Thy1+ neurons and Thy1- neurons. (F) Representative traces showing GABA-induced tonic GABAAR currents recorded in Thy1+ and Thy1- neurons from control and CSDS mice. (G) Comparison of GABA-induced tonic GABAAR currents in Thy1+ and Thy1- neurons. *p < 0.05, **p < 0.01, ***p < 0.001. Pooled data are presented as mean ± SEM.