FIGURE 5.

Biofilm disruption by ficin alone and in combination with dalbavancin. (A) Biofilm treatment by ficin [marked as F (1,000, 100, and 10 mg/L)] and dalbavancin [marked as D (32 mg/L)], either alone or in combination (F1000 D32), in methicillin-resistant Staphylococcus aureus strain MRSA4. Ficin, dalbavancin, or both was added on established biofilms after 7 h of growth in an xCELLigence equipment. (B) Effect of ficin on planktonic bacterial growth, measured as optical density in a 96-well plate. Bacteria were grown on TSB supplemented with 0.25% glucose at 37°C. Data are the means of three replicates.