FIGURE 1.

(A) Matrix mechanics can be modulated to create stiff or soft synthetic microenvironment, while device-driven tissue manipulation can impose mechanical stresses directly on tissues. Such manipulation provides global and homogenous mechanical cues on tissues and organoids. (B) Magnetic NPs can be tailored to matrix or tissue mechanics applications. NPs activated by a field can generate local mechanical forces, while inactive ones can passively alter local matrix stiffness. Magnetized cells can be subjected to forces by an external field and transfer these mechanical stresses to the surrounding tissue.