FIGURE 2.

Inhibition of HDAC11 by quisinostat attenuates renal fibrosis in mice. Renal fibrosis was induced in C57/BL6 mice by UUO. After the surgery, the mice were injected with quisinostat or vehicle as described in section “Materials and Methods.” (A–E) Expression levels of Col1a1 (A), Col1a1 (B), Col3a1 (C), Acta2 (D), and Tgfb (E) were examined by qPCR. (F,G) Paraffin sections were stained with picrosirius red and Masson’s trichrome. (H) Hydroxylproline levels. (I) Plasma BUN levels. (J) Plasma creatinine levels. N = 7∼9 mice for each group.