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. 2020 Apr 17;8:327. doi: 10.3389/fbioe.2020.00327

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Copyright © 2020 Nossin, Farrell, Koevoet, Somoza, Caplan, Brachvogel and van Osch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selection pipeline for factors of interest. Diagram of the selection process of factors of interest starting from a growth plate microarray going through the selection of secreted, angiogenesis regulating factors via online resources ending at the comparison to a human dataset including neonatal cartilage and chondrogenically differentiated BMSC data. Twenty-six factors were identified being differentially expressed between the growth plate zones, secreted and regulate angiogenesis (Venn-diagram). From these, 8 factors appeared differentially expressed between human chondrogenically differentiated BMSC and neonatal articular cartilage.