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. 2020 Apr 17;10:545. doi: 10.3389/fonc.2020.00545

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Copyright © 2020 Wencong, Jinghan, Yong, Jianyang, Bin, Qingbao, Chen and Xiaoqing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depletion of FOXK1 attenuates xenograft tumor growth in vivo. (A,B) Representative images of sacrificed nude mice (A) and xenograft tumors (B) derived from subcutaneous implantation of NOZ cells treated with Lv-shFOXK1 or Lv-shNC. (C) Tumor growth curves in different group were calculated in a 4-week course (*P < 0.05, **P < 0.01, and ***P < 0.001). (D) Comparison of tumor weight between shFOXK1 group and shNC group (*P < 0.05, **P < 0.01, and ***P < 0.001). (E) Paraffin sections were stained for IHC with antibodies against ki-67, scale bar =20 μm.