Table 2.

Univariate and multivariate analysis of the association of prognosis with clinicopathological parameters and FOXK1 expression in GBC patients.

Variable	Univariable analysis		Multivariable analysis
	HR (95% CI)	P	HR (95% CI)	P
Sex (male vs. female)	1.098 (0.637–1.893)	0.737
Age (≥60 vs. <60)	1.054 (0.623–1.784)	0.844
Gallbladder stone (present vs. absent)	1.860 (1.015–3.411)	0.045	2.551 (1.353–4.812)	0.004
Histology differentiation (Poor vs. Well/moderate)	1.782 (1.014–3.132)	0.045
Lymph node metastasis (present vs. absent)	2.201 (1.274-3.803)	0.005	2.775 (1.529-5.037)	0.001
Liver metastasis (present vs. absent)	2.324 (1.249–4.326)	0.008
TNM stage (III-IV vs. I-II)	2.621 (1.371–5.011)	0.004	2.585 (1.345–4.968)	0.004
FOXK1 expression (high vs. low)	2.236 (1.231–4.059)	0.008	1.896 (1.027-3.499)	0.041

Bold values indicate statistical significance, P < 0.05, CI, confidence interval; HR, hazard ratio.