TABLE 1.

Immobilized PEL-catalyzed acylation of arbutin with vinyl vanillic acid in co-sol vent mixtures.

Medium	Time (h)	Conversion (%)	6′-Regioselectivity (%)
THF	1	1.6	>99
	96	30	>99
THF-Hexane (25%, v/v)	1	4.6	>99
	88	40	>99
THF-Isooctane (25%, v/v)	1	8.9	>99
	80	66	>99
THF-Cyclohexane (25%, v/v)	1	8.6	>99
	80	66	>99
THF-t-Butanol (25%, v/v)	1	2.9	>99
	92	32	>99
THF-Isopropyl ether (25%, v/v)	1	10.8	>99
	76	70	>99

Reaction conditions: 0.04 mmol arbutin, 0.20 mmol vinyl vanillic acid, 50 U/mL immobilized PEL, 2 mL anhydrous solvents, 50°C, 200 r/min.