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. 2020 Apr 17;14:72. doi: 10.3389/fncel.2020.00072

Figure 1.

Figure 1

Gene ontology (GO) analysis of LOAD risk factors reveals the enrichment of genes in the trafficking pathway. Nearly half of the 37 LOAD putative risk factors identified by genome-wide association studies (GWAS) meta-analysis (Lambert et al., 2013; Jansen et al., 2019; Kunkle et al., 2019), have been functionally grouped by GO analysis in three main pathways: trafficking (orange), immune response (blue), and lipid metabolism (green). GO analysis was performed using the Cytoscape StringApp (Doncheva et al., 2019).