TABLE 6.
Test kit | Fixed specificity |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
99% |
98% |
97% |
96% |
95% |
90% |
|||||||
% | P | % | P | % | P | % | P | % | P | % | P | |
BioPlex 2200 Lyme Total | 91.1 | Ref | 91.1 | Ref | 91.1 | Ref | 92.2 | Ref | 92.2 | Ref | 95.6 | Ref |
Immunetics Lyme C6 | 82.2 | 0.008 | 83.3 | 0.016 | 86.7 | 0.125 | 86.7 | 0.063 | 86.7 | 0.063 | 88.9 | 0.031 |
Zeus Borrelia VlsE1/pepC10 | 76.7 | <0.001 | 84.4 | 0.031 | 84.4 | 0.031 | 86.7 | 0.063 | 87.8 | 0.125 | 88.9 | 0.031 |
bioMérieux VIDAS Lyme polyvalent | 47.8 | <0.001 | 71.1 | <0.001 | 74.4 | <0.001 | 75.6 | <0.001 | 75.6 | <0.001 | 82.2 | 0.002 |
bioMérieux VIDAS Lyme II (lgM+IgG) | 77.8 | <0.001 | 77.8 | <0.001 | 77.8 | <0.001 | 80.0 | 0.001 | 80.0 | 0.001 | 83.3 | 0.001 |
bioMérieux VIDAS Lyme II lgM | 50.0 | <0.001 | 50.0 | <0.001 | 52.2 | <0.001 | 57.8 | <0.001 | 58.9 | <0.001 | 67.8 | <0.001 |
bioMérieux VIDAS Lyme II lgG | 77.8 | <0.001 | 84.4 | 0.031 | 84.4 | 0.031 | 84.4 | 0.016 | 84.4 | 0.016 | 84.4 | 0.002 |
The ROC curves generated in Fig. 1 were used to measure the predicted sensitivity of the Lyme assays at the selected specificity levels shown. Ref, reference.