Table 9.

Case studies – Modes and methods.

Study	Personalised treatment intervention	Other Modes	Methods
Bredesen et al. (2016) USA	MEND Protocol – Nutrition (diet, vitamins, supplementation, herbs, antioxidants) FastingResponsive to suboptimal metabolic parameters; continued optimization, iterative treatment and metabolic characterization	Sleep Stress Exercise Brain stimulation Hormones GI health Detoxification	Sleep hygiene, stress reduction, aerobics, strength training, brain training, hormone therapy, intranasal vasoactive intestinal peptide (VIP), address heavy metal toxicity
Prokopov (2010) Spain	Repeated sessions of Intermittent Hypoxic Training (IHT) Patients comfortably relax in a recliner, their cells and mitochondria go through multiple oscillations of pO2. Intermittent oxygen restriction (IOR) is a universal stimulus rapidly triggering multiple compensatory strategies that support genome integrity.	Nutritional adjustmentIndividualized vitamins, amino acids, microelements and supplementation Fasting	Advised to eat a low-glycaemic-index, low carbohydrate, ketogenic diet, enriched with animal proteins & omega-3 fatty acids. Advised on fasting protocol: limit food intake to within 6–7 h window to extend physiological night fasting time to 18 h