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. 2020 Apr 17;12:103. doi: 10.3389/fnagi.2020.00103

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Copyright © 2020 Arbo, André-Miral, Nasre-Nasser, Schimith, Santos, Costa-Silva, Muccillo-Baisch and Hort.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuroprotective mechanisms described for Resveratrol. *Some studies did not evidence any involvement of SIRT-1 in the neuroprotective actions of RV against MPP+. Symbols: ↓: decrease; ↑: increase. Abbreviations: α-syn: alfa-synuclein; Aβ: amyloid-beta, Akt: protein kinase B, AMPK: AMP-activated protein kinase, CAT: catalase, COX-2: cyclooxygenase-2, GPx: glutathione peroxidase, GSH: glutathione, HO-1: heme oxygenase 1, IL: interleukins, MCP-1: chemokine monocyte chemotactic protein-1, NF-κB: nuclear factor kappa B, NO: nitric oxide, p53: tumor protein p53, PI3K: phosphatidylinosi-tol 3-kinase, ROS: reactive oxygen species, SIRT-1: anti-aging factor sirtuin-1, SOD: superoxide dismutase, TNF-α: tumor necrosis factor-α.