TABLE 1.
Patient Characteristics
| Characteristic | No. of Patients (%) | |
|---|---|---|
| All Patients, n = 85 | Quadruplet Arm 7: Memantine, Mefloquine, and Metformin, n = 22 | |
| Age: Median [range], y | 53 [21–77] | 53 [34–68] |
| Sex | ||
| Men | 54 (64) | 11 (50) |
| Women | 31 (36) | 11 (50) |
| Karnofsky performance status, | ||
| 100 | 37 (44) | 8 (36) |
| 90 | 30 (35) | 11 (50) |
| 80 | 12 (14) | 3 (14) |
| 70 | 6 (7) | 0 (0) |
| Extent of resection | ||
| Biopsy | 10 (12) | 3 (14) |
| Partial resection | 23 (27) | 9 (41) |
| Gross total resection | 52 (61) | 10 (45) |
| IDH status | ||
| Not available | 24 (30) | 3 (14) |
| Mutateda | 8/61 (13) | 1/19 (5) |
| Wild typeb | 53/61 (87) | 18/19 (95) |
Abbreviations: IDH, isocitrate dehydrogenase; IHC, immunohistochemistry;
a
In the IDH-mutated group, of all patients, 4 were tested by IHC only, and 4 were tested by IHC and polymerase chain reaction (PCR); and, in quadruplet arm 7, 1 patient was tested by IHC and PCR.
b
In the IDH wild-type group, of all patients, 5 were tested by IHC only (including 2 patients aged >55 years), 42 were tested by PCR for IDH1/IDH2, and 6 were tested by PCR IDH1 only; and, in quadruplet arm 7, 3 were tested by IHC only (including 2 patients aged >55 years), and 15 patients were tested by PCR for IDH1/IDH2.