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NaB regulates a variety of AD-related genes in N2a cells. N2a cells were treated with 0, 1, 2, and 3 mM NaB for 24 hours. (a–d) The mRNA expressions of APP, BENF, NEP, and GPR109A were assessed by RT-PCR (n = 3, means ± SD, Student's t-test, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001). The effect of NaB on N2a cells is most obvious when the concentration is 2 mM.
