Figure 7.

Cell cycle arrest and cell death induction by dual CK2-HDAC inhibitors. (A) the impact of the indicated compound doses on the distribution of Jurkat T-leukemia cells in the different phases of the cell cycle was determined by FACS of propidium iodide-stained cells after 24 h of continuous exposure. (B) evaluation of the impact of selected dual CK2-HDAC inhibitors (10 µM and 30 µM, 24 h) on phosphatidylserine externalization in Jurkat T-leukemia cells was determined by FACS, using FITC-labeled annexin V and PI staining. One of three experiments delivering comparable data is shown.