ATP |
adenosine triphosphate |
CK2 |
Protein kinase 2 |
BSA |
Bovine Serum Albumin |
CuAAC |
Cu (I)-catalyzed alkyne azide cycloaddition |
DCFDA |
2′,7′ –dichlorofluorescin diacetate |
DCM |
dichloromethane |
DMAT |
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole |
DMF |
dimethylformamide |
DMSO |
dimethyl sulfoxide |
EDCI |
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide |
EGFR |
epidermal growth factor receptor |
FACS |
Fluorescence-activated cell sorting |
FITC |
Fluorescein isothiocyanate |
HAT |
histone acetyl transferase |
HDAC |
histone deacetylase |
HER2 |
human epidermal growth factor receptor 2 |
HOBt |
1-hydroxybenzotriazole |
JAK2 |
Janus kinase 2 |
LC50 |
lethal concentration 50 |
LMD |
molecular dynamics |
MDR |
multi-drug resistance |
MTD |
multitarget drugs |
MW |
microwave |
NMM |
N-Methylmorpholine |
OTHP |
2-tetrahydropyranyl |
PI3K |
osfoinositol 3-quinasa |
RMSD |
root-mean-square deviation |
ROS |
reactive oxygen species |
RT |
room temperature |
SAR |
structure activity relationship |
SRM |
surface recognition moiety |
TBB |
tetrabromobenzotriazole |
TBI |
tetrabromobenzimidazole |
TBTA |
Tris(benzyltriazolyl)methylamine |
THF |
Tetrahydrofuran |
TsOH |
p-Toluenesulfonic acid |
ZBG |
Zinc binding group |