Table 2.
LC50 values of studied CK2-HDAC dual inhibitors towards human tumor and pseudonormal cell lines in vitro.
| Comp | LC50 Values of Compounds for Cell Line, µM (M ± SD) | ||||||
|---|---|---|---|---|---|---|---|
| Jurkat | MCF-7 | HCT-116 | HEK293 | HL-60 | HL-60/adr | HL-60/vinc | |
| 11b | 10.15 ± 1.43 | 15.66 ± 2.54 | 4.22 ± 0.46 | 23.33 ± 4.38 | 7.67 ± 1.17 | 16.23 ± 1.68 | 16.79 ± 3.34 |
| 11c | 9.47 ± 1.10 | 9.97 ± 0.99 | 1.90 ± 0.24 | 13.61 ± 0.80 | 6.59 ± 0.96 | 10.63 ± 1.53 | 12.06 ± 3.27 |
| 11d | 5.30 ± 0.75 | 9.02 ± 0.90 | 3.10 ± 0.37 | 8.41 ± 1.26 | 4.69 ± 0.54 | 8.4 ± 1.21 | 2.32 ± 1.06 |
| 7c | 16.54 ± 2.33 | 27.75 ± 6.06 | 16.87 ± 3.90 | 42.71 ± 8.65 | 24.02 ± 8.66 | 18.58 ± 2.09 | 49.46 ± 9.47 |
| 15a | 43.58 ± 16.73 | 13.66 ± 2.67 | 8.67 ± 1.02 | 33.73 ± 7.52 | 34.42 ± 7.89 | 32.37 ± 3.44 | 36.55 ± 4.74 |
| 19 | 24.86 ± 3.80 | 13.55 ± 0.78 | 11.3 ± 1.01 | 33.36 ± 11.76 | 46.49 ± 17.31 | 32.31 ± 5.32 | 21.73 ± 3.39 |