Bax, Bid	The Bcl-2 family proteins promote apoptosis by governing mitochondrial outer membrane permeabilization (MOMP).
Bcl-2, Mcl-1, Bcl-xL	The Bcl-2 family proteins promote apoptosis by governing mitochondrial outer membrane permeabilization (MOMP).
Cdc2	Cell division cycle protein 2 (also known as CDK1, cyclin-dependent kinase 1). It is a key player in cell cycle regulation. The activity of CDK1 oscillates during each cell cycle, which peaks at the G2/M phase and remains low at G1/S phase.
Cdc25C	A tyrosine phosphatase protein belonging to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B/CDK1 and triggers entry into mitosis.
Cyclin D1	Cyclin which forms a complex with CDK4 or CDK6, whose activity is required for cell cycle G1/S transition.
DAPK	Death-associated protein kinase. Depletion of DAPK1 results in inhibition of tumor cell count.
DIABLO	A mitochondrial protein, inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis.
H2AX	A type of histone protein. An phosphorylated form (γH2AX) is formed when double-strand breaks appear.
MAPK	A mitogen-activated protein kinase (including ERK, JNK and others). MAPKs regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival and apoptosis.
mTOR	The mammalian target of rapamycin protein is a kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy and transcription. mTOR also senses cellular nutrient, oxygen and energy levels. Phosphorylation of ribosomal S6 (S6R) protein is considered a robust readout for mTOR activation. The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.
Notch 1	Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.
NOXA	Promotes activation of caspases, mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria.
p21	Cyclin-dependent kinase inhibitor 1. It represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest.
p53	Protein plays a role in regulation or progression through the cell cycle, apoptosis, and genomic stability.
PARP	Poly (ADP-ribose) polymerase is involved in a number of cellular processes such as DNA repair, genomic stability, and programed cell death.
PI3K	Phosphoinositide 3-kinases. a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival. The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in regulating the cell cycle.
PKB/Akt	Protein kinase B (PKB or Akt) plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. Activation of PKB was shown to overcome cell cycle arrest in G1 and G2 phases.
Rac-1	Small signaling G proteins which are pleiotropic regulators of many cellular processes, including the cell cycle, cell–cell adhesion, motility. Rac-1 activates NADPH oxidase inducing ROS generation.
RAGE	Receptor for advanced glycation end products. Overexpression of RAGE in pancreatic cancer cells is associated with enhanced autophagy, diminished apoptosis and greater tumor cell viability.
Rb	The retinoblastoma protein prevents excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. Rb is phosphorylated to pRb leading to the inactivation of the activity of Retinoblastoma protein. It allows cells to enter into the cell cycle state. Rb is dysfunctional in many cancers.
RET/PTC1	The most prevalent type of gene rearrangement found in papillary thyroid carcinoma.
VEGF	Vascular endothelial growth factor is a signal protein produced by cells that stimulates the formation of blood vessels.