Table 2.
Cytotoxicity of compounds 6, 8, 16, 17, 22, 24 and 25 in four mammalian cell lines.
| Compound | CC50 a (µM) | |||
|---|---|---|---|---|
| Hep-2 | HEL | Vero | MDCK | |
| 6 | >100 | >100 | >100 | >100 |
| 8 | >100 | >100 | 44 | >100 |
| 16 | >100 | >100 | >100 | >100 |
| 17 | 48 | >100 | 43 | >100 |
| 22 | >100 | 100 | >100 | >100 |
| 24 | >100 | >100 | 51 | 35 |
| 25 | >100 | >100 | >100 | 33 |
| Zanamivir | - | - | - | >100 |
| Ribavirin | >250 | - | >250 | >100 |
| DS-10,000 b | >100 | - | >100 | - |
| UDA b | - | >100 | - | - |
a CC50: 50% cytotoxic concentration based on the MTS cell viability assay. Hep-2: human epithelial type 2 cells; HEL: human embryonic lung fibroblast cells; Vero: African green monkey kidney cells; MDCK: Madin–Darby canine kidney cells. b For dextran sulfate MW 10,000 (DS-10,000) and UDA lectin, concentrations are in µg/mL.