Table 2.
In vitro antimycobacterial activity (expressed as MIC in µg/mL) against non-tuberculous mycobacterial strains of M. kansasii and M. avium.a
| No. | R1 | R2 |
Mycobacterium
kansasii |
Mycobacterium
avium |
|---|---|---|---|---|
| 3c | 4-OH | Pentyl | 12.5 | 50 |
| 3f | 4-OH | Octyl | 6.25 | >100 |
| 4d | 4-CH3 | Hexyl | 12.5 | >100 |
| 4e | 4-CH3 | Heptyl | 12.5 | >100 |
| 6c | 4-Cl-2-OH | Pentyl | 25 | >100 |
| 6d | 4-Cl-2-OH | Hexyl | 25 | >100 |
| 6e | 4-Cl-2-OH | Heptyl | 25 | >100 |
| INH | 25 | 25 | ||
a Compounds 1, 1a, 1c, 1f, 2, 3, 3d, 3e, 4, 5, 5f, 6, 6f, and 7 were not tested in this study. Other compounds not mentioned in the table were inactive against both strains (MIC > 100 µg/mL).