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Significant anti-candidal activity of final compounds expressed as MIC in µM.
| No. | R1 | R2 | CA | CK | CP |
|---|---|---|---|---|---|
| 1c | 3-CF3 | Pentyl | >125 | 62.5 | 125 |
| 2a | 3-OH | Propyl | >125 | 62.5 | >125 |
| 3b | 4-OH | Butyl | 62.5 | >250 | 250 |
| 3c | 4-OH | Pentyl | 62.5 | >125 | >125 |
| 4d | 4-CH3 | Hexyl | >125 | 125 | 125 |
| Amphotericin B | 0.5 µg/mL (0.54 µM) | 1 µg/mL (1.08 µM) | 0.5 µg/mL (0.54 µM) | ||
CA—Candida albicans; CK—Candida krusei; CP—Candida parapsilosis.
